Melatonin enhances TNF-α-mediated cervical cancer HeLa cells death via suppressing CaMKII/Parkin/mitophagy axis

Melatonin enhances TNF-α-mediated cervical cancer HeLa cells death via suppressing CaMKII/Parkin/mitophagy axis

Abstract Background Tumor necrosis factor-α (TNF-α) immunotherapy controls the progression of human cervical cancer. Here, we explored the detailed molecular mechanisms played by melatonin in human cervical cancer (HeLa cells) death in the presence of TNF-α injury, with a particular attention to the...

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Bibliographic Details
Main Authors: Qinghe Zhao, Wuliang Wang, Jinquan Cui
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Cancer Cell International
Subjects:
Melatonin
Mitochondria
HeLa cell
CaMKII/Parkin pathways
TNF-α
Online Access:http://link.springer.com/article/10.1186/s12935-019-0777-2

Internet

http://link.springer.com/article/10.1186/s12935-019-0777-2

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