Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer

Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer

Inhibition of glycolysis using 2-deoxy-d-glucose (2DG, 20 mM, 24–48 h) combined with inhibition of the pentose cycle using dehydroepiandrosterone (DHEA, 300 µM, 24–48 h) increased clonogenic cell killing in both human prostate (PC-3 and DU145) and human breast (MDA-MB231) cancer cells via a mechani...

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Bibliographic Details
Main Authors: Ling Li, Melissa A. Fath, Peter M. Scarbrough, Walter H. Watson, Douglas R. Spitz
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Redox Biology
Subjects:
Dehydroepiandrosterone
Pentose phosphate pathway
Oxidative stress
Auranofin
Buthionine sulfoximine
Glutathione
Thioredoxin
2-Deoxy-d-glucose
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231714001256

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http://www.sciencedirect.com/science/article/pii/S2213231714001256

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