Changes in Astrocyte Shape Induced by Sublytic Concentrations of the Cholesterol-Dependent Cytolysin Pneumolysin Still Require Pore-Forming Capacity

Changes in Astrocyte Shape Induced by Sublytic Concentrations of the Cholesterol-Dependent Cytolysin Pneumolysin Still Require Pore-Forming Capacity

Streptococcus pneumoniae is a common pathogen that causes various infections, such as sepsis and meningitis. A major pathogenic factor of S. pneumoniae is the cholesterol-dependent cytolysin, pneumolysin. It produces cell lysis at high concentrations and apoptosis at lower concentrations. We have sh...

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Bibliographic Details
Main Authors: Christina Förtsch, Roland Benz, Asparouh I. Iliev, Jiangtao Ma, Timothy J. Mitchell, Elke Maier, Sabrina Hupp
Format: Article
Language:English
Published: MDPI AG 2011-01-01
Series:Toxins
Subjects:
pneumolysin
pore formation
cytoskeleton
Online Access:http://www.mdpi.com/2072-6651/3/1/43/

Internet

http://www.mdpi.com/2072-6651/3/1/43/

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