Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity

Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity

Previous studies have reported that modification of histones alters aminoglycoside-induced hair cell death and hearing loss. In this study, we investigated three FDA-approved histone deacetylase (HDAC) inhibitors (vorinostat/SAHA, belinostat, and panobinostat) as protectants against aminoglycoside-i...

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Bibliographic Details
Main Authors: Chao-Hui Yang, Zhiqi Liu, Deanna Dong, Jochen Schacht, Dev Arya, Su-Hua Sha
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
ototoxicity
HDAC inhibitors
prevention of aminoglycoside-induced hearing loss
modification of histone acetylation
acute and chronic animal models
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00315/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00315/full

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