Functional analysis of plasma α2-macroglobulin from Alzheimer's disease patients with the A2M intronic deletion
α2-Macroglobulin (α2M) is an abundant plasma/extracellular space protein implicated in clearance of amyloid β (Aβ), a key constituent of Alzheimer's disease (AD) plaques. α2M also regulates proteinase and growth factor activities. In recent years, there have been >30 genetic studies debating...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2003-12-01
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| Series: | Neurobiology of Disease |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996103001505 |