JAK-STAT-mediated chronic inflammation impairs cytotoxic T lymphocyte activation to decrease anti-PD-1 immunotherapy efficacy in pancreatic cancer

JAK-STAT-mediated chronic inflammation impairs cytotoxic T lymphocyte activation to decrease anti-PD-1 immunotherapy efficacy in pancreatic cancer

Human pancreatic cancer does not respond to immune check point blockade immunotherapy. One key feature of pancreatic cancer is the association between its progression and chronic inflammation. Emerging evidence supports a key role for the JAK-STAT pathway in pancreatic cancer inflammation. We aimed...

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Bibliographic Details
Main Authors: Chunwan Lu, Asif Talukder, Natasha M. Savage, Nagendra Singh, Kebin Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2017-03-01
Series:OncoImmunology
Subjects:
cytotoxic t lymphocytes
fasl
pd-1
pd-l1
ruxolitinib
stat1
stat3
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1291106

Internet

http://dx.doi.org/10.1080/2162402X.2017.1291106

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