A Split Luciferase Complementation Assay for the Quantification of β-Arrestin2 Recruitment to Dopamine D<sub>2</sub>-like Receptors

A Split Luciferase Complementation Assay for the Quantification of β-Arrestin2 Recruitment to Dopamine D<sub>2</sub>-like Receptors

Investigations on functional selectivity of GPCR ligands have become increasingly important to identify compounds with a potentially more beneficial side effect profile. In order to discriminate between individual signaling pathways, the determination of β-arrestin2 recruitment, in addition to G-pro...

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Bibliographic Details
Main Authors: Lisa Forster, Lukas Grätz, Denise Mönnich, Günther Bernhardt, Steffen Pockes
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
GPCR
dopamine D2-like receptors
β-arrestin
GRK
Emerald luciferase
functional assay
Online Access:https://www.mdpi.com/1422-0067/21/17/6103

Internet

https://www.mdpi.com/1422-0067/21/17/6103

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