HDAC6 Inhibition Alleviates CLL-Induced T-Cell Dysfunction and Enhances Immune Checkpoint Blockade Efficacy in the Eμ-TCL1 Model

HDAC6 Inhibition Alleviates CLL-Induced T-Cell Dysfunction and Enhances Immune Checkpoint Blockade Efficacy in the Eμ-TCL1 Model

Development of chronic lymphocytic leukemia (CLL) is associated with severe immune dysfunction. T-cell exhaustion, immune checkpoint upregulation, and increase of regulatory T cells contribute to an immunosuppressive tumor microenvironment. As a result, CLL patients are severely susceptible to infec...

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Bibliographic Details
Main Authors: Kamira Maharaj, John J. Powers, Melanie Mediavilla-Varela, Alex Achille, Wael Gamal, Steven Quayle, Simon S. Jones, Eva Sahakian, Javier Pinilla-Ibarz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
chronic lymphocytic leukemia
immune checkpoint
PD-1
PD-L1
HDAC6
histone deacetylase
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.590072/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.590072/full

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