Sperm-Specific Glycolysis Enzyme Glyceraldehyde-3-Phosphate Dehydrogenase Regulated by Transcription Factor SOX10 to Promote Uveal Melanoma Tumorigenesis

Sperm-Specific Glycolysis Enzyme Glyceraldehyde-3-Phosphate Dehydrogenase Regulated by Transcription Factor SOX10 to Promote Uveal Melanoma Tumorigenesis

Melanoma cells exhibit increased aerobic glycolysis, which represents a major biochemical alteration associated with malignant transformation; thus, glycolytic enzymes could be exploited to selectively target cancer cells in cancer therapy. Sperm-specific glyceraldehyde-3-phosphate dehydrogenase (GA...

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Bibliographic Details
Main Authors: Xia Ding, Lihua Wang, Mingjiao Chen, Yue Wu, Shengfang Ge, Jin Li, Xianqun Fan, Ming Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
sperm-specific glyceraldehyde-3-phosphate dehydrogenase
glycolysis
uveal melanoma
SOX10
glycolytic enzyme
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.610683/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.610683/full

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