The Homeobox Transcription Factor RHOX10 Drives Mouse Spermatogonial Stem Cell Establishment

The Homeobox Transcription Factor RHOX10 Drives Mouse Spermatogonial Stem Cell Establishment

The developmental origins of most adult stem cells are poorly understood. Here, we report the identification of a transcription factor—RHOX10—critical for the initial establishment of spermatogonial stem cells (SSCs). Conditional loss of the entire 33-gene X-linked homeobox gene cluster that include...

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Bibliographic Details
Main Authors: Hye-Won Song, Anilkumar Bettegowda, Blue B. Lake, Adrienne H. Zhao, David Skarbrevik, Eric Babajanian, Meena Sukhwani, Eleen Y. Shum, Mimi H. Phan, Terra-Dawn M. Plank, Marcy E. Richardson, Madhuvanthi Ramaiah, Vaishnavi Sridhar, Dirk G. de Rooij, Kyle E. Orwig, Kun Zhang, Miles F. Wilkinson
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
spermatogonial stem cells
spermatogonia
spermatogenesis
germ cell
germ line stem cell
homeobox
Rhox
transcription factor
gonocytes
prospermatogonia
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716311998

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http://www.sciencedirect.com/science/article/pii/S2211124716311998

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