Survival motor neuron protein regulates oxidative stress and inflammatory response in microglia of the spinal cord in spinal muscular atrophy

Survival motor neuron protein regulates oxidative stress and inflammatory response in microglia of the spinal cord in spinal muscular atrophy

The deficiency of survival motor neuron (SMN) protein can result in the onset of spinal muscular atrophy (SMA), an autosomal recessive disorder characterized by a progressive loss of motor neurons and skeletal muscle atrophy. The mechanism underlying SMA pathology remains unclear. Here, we demonstra...

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Bibliographic Details
Main Authors: Shiori Ando, Daiki Osanai, Kei Takahashi, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Journal of Pharmacological Sciences
Subjects:
Antisense oligonucleotide
Macrophage cell
Righting reflex
ROS production
SMA model mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300906

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http://www.sciencedirect.com/science/article/pii/S1347861320300906

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