Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance.

Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance.

DNA polymerase ν (pol ν), encoded by the POLN gene, is an A-family DNA polymerase in vertebrates and some other animal lineages. Here we report an in-depth analysis of pol ν-defective mice and human cells. POLN is very weakly expressed in most tissues, with the highest relative expression in testis....

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Bibliographic Details
Main Authors: Kei-Ichi Takata, Shelley Reh, Matthew J Yousefzadeh, Maciej J Zelazowski, Sarita Bhetawal, David Trono, Megan G Lowery, Maria Sandoval, Yoko Takata, Yue Lu, Kevin Lin, Jianjun Shen, Donna F Kusewitt, Kevin M McBride, Francesca Cole, Richard D Wood
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5472330?pdf=render

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http://europepmc.org/articles/PMC5472330?pdf=render

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