Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons

Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons

Huntington’s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs). To better understand the mechanisms underlying this deficit, striatal neurons in...

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Bibliographic Details
Main Authors: Luis Carrillo-Reid, Michelle Day, Zhong Xie, Alexandria E Melendez, Jyothisri Kondapalli, Joshua L Plotkin, David L Wokosin, Yu Chen, Geraldine J Kress, Michael Kaplitt, Ema Ilijic, Jaime N Guzman, C Savio Chan, D James Surmeier
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
Huntington's disease
dendrite
Kv4
KChIP
zinc finger protein
calcium imaging
Online Access:https://elifesciences.org/articles/40818

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