Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons

Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons

Huntington’s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs). To better understand the mechanisms underlying this deficit, striatal neurons in...

Full description

Bibliographic Details
Main Authors: Luis Carrillo-Reid, Michelle Day, Zhong Xie, Alexandria E Melendez, Jyothisri Kondapalli, Joshua L Plotkin, David L Wokosin, Yu Chen, Geraldine J Kress, Michael Kaplitt, Ema Ilijic, Jaime N Guzman, C Savio Chan, D James Surmeier
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
Huntington's disease
dendrite
Kv4
KChIP
zinc finger protein
calcium imaging
Online Access:https://elifesciences.org/articles/40818

Internet

https://elifesciences.org/articles/40818

Similar Items