When the genome plays dice: circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitoses.

When the genome plays dice: circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitoses.

<h4>Background</h4>Normal cell division is coordinated by a bipolar mitotic spindle, ensuring symmetrical segregation of chromosomes. Cancer cells, however, occasionally divide into three or more directions. Such multipolar mitoses have been proposed to generate genetic diversity and the...

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Bibliographic Details
Main Authors: David Gisselsson, Ulf Håkanson, Patrick Stoller, Dominik Marti, Yuesheng Jin, Anders H Rosengren, Ylva Stewénius, Fredrik Kahl, Ioannis Panagopoulos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-04-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18392149/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18392149/pdf/?tool=EBI

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