Discovery of Potential Flavonoid Inhibitors Against COVID-19 3CL Proteinase Based on Virtual Screening Strategy

Discovery of Potential Flavonoid Inhibitors Against COVID-19 3CL Proteinase Based on Virtual Screening Strategy

The outbreak of 2019 novel coronavirus (COVID-19) has caused serious threat to public health. Discovery of new anti-COVID-19 drugs is urgently needed. Fortunately, the crystal structure of COVID-19 3CL proteinase was recently resolved. The proteinase has been identified as a promising target for dru...

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Bibliographic Details
Main Authors: Zhongren Xu, Lixiang Yang, Xinghao Zhang, Qiling Zhang, Zhibin Yang, Yuanhao Liu, Shuang Wei, Wukun Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
COVID-19 3CL proteinase
flavonoids
rutin
virtual screening
machine learning
molecular docking
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.556481/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2020.556481/full

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