Antitumor Effects of Rapamycin in Pancreatic Cancer Cells by Inducing Apoptosis and Autophagy

Antitumor Effects of Rapamycin in Pancreatic Cancer Cells by Inducing Apoptosis and Autophagy

Rapamycin (Rapa), an inhibitor of mammalian target of Rapamycin (mTOR), is an immunosuppressive agent that has anti-proliferative effects on some tumors. This study aims to investigate the effects of Rapa suppressing proliferation of pancreatic carcinoma PC-2 cells in vitro and its molecular mechani...

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Bibliographic Details
Main Authors: Xi-Jing Wang, Shuai Lin, Wang-Feng Lu, Bao-Feng Wang, Hua-Feng Kang, Xiao-Bin Ma, Jie Gao, Zhi-Jun Dai, Wen-Ying Wu
Format: Article
Language:English
Published: MDPI AG 2012-12-01
Series:International Journal of Molecular Sciences
Subjects:
pancreatic carcinoma
rapamycin
mTOR
anti-tumor
apoptosis
autophagy
Online Access:http://www.mdpi.com/1422-0067/14/1/273

Internet

http://www.mdpi.com/1422-0067/14/1/273

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