Subchronic <i>N</i>-acetylcysteine Treatment Decreases Brain Kynurenic Acid Levels and Improves Cognitive Performance in Mice

Subchronic <i>N</i>-acetylcysteine Treatment Decreases Brain Kynurenic Acid Levels and Improves Cognitive Performance in Mice

The tryptophan (Trp) metabolite kynurenic acid (KYNA) is an α7-nicotinic and <i>N</i>-methyl-d-aspartate receptor antagonist. Elevated brain KYNA levels are commonly seen in psychiatric disorders and neurodegenerative diseases and may be related to cognitive impairments. Recently, we sho...

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Bibliographic Details
Main Authors: Tonali Blanco Blanco Ayala, Daniela Ramírez Ramírez Ortega, Paulina Ovalle Ovalle Rodríguez, Benjamín Pineda, Gonzalo Pérez de la Pérez de la Cruz, Dinora González González Esquivel, Robert Schwarcz, Korrapati V. Sathyasaikumar, Anabel Jiménez Jiménez Anguiano, Verónica Pérez de la Pérez de la Cruz
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Antioxidants
Subjects:
<i>N</i>-acetylcysteine
kynurenic acid
kynurenine
learning and memory
Online Access:https://www.mdpi.com/2076-3921/10/2/147

Internet

https://www.mdpi.com/2076-3921/10/2/147

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