The pharmacokinetics of [18F]UCB-H revisited in the healthy non-human primate brain

The pharmacokinetics of [18F]UCB-H revisited in the healthy non-human primate brain

Abstract Background Positron Emission Tomography (PET) imaging of the Synaptic Vesicle glycoprotein (SV) 2A is a new tool to quantify synaptic density. [18F]UCB-H was one of the first promising SV2A-ligands to be labelled and used in vivo in rodent and human, while limited information on its pharmac...

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Bibliographic Details
Main Authors: Sébastien Goutal, Martine Guillermier, Guillaume Becker, Mylène Gaudin, Yann Bramoullé, André Luxen, Christian Lemaire, Alain Plenevaux, Eric Salmon, Philippe Hantraye, Olivier Barret, Nadja Van Camp
Format: Article
Language:English
Published: SpringerOpen 2021-04-01
Series:EJNMMI Research
Subjects:
SV2A
Cynomolgus non-human Primates
PET
Synaptic imaging
Online Access:https://doi.org/10.1186/s13550-021-00777-8

Internet

https://doi.org/10.1186/s13550-021-00777-8

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