Short Hairpin RNA (shRNA) Ether à go-go 1 (Eag1) Inhibition of Human Osteosarcoma Angiogenesis via VEGF/PI3K/AKT Signaling

Short Hairpin RNA (shRNA) Ether à go-go 1 (Eag1) Inhibition of Human Osteosarcoma Angiogenesis via VEGF/PI3K/AKT Signaling

Ether à go-go 1 (Eag1) channel is overexpressed in a variety of cancers but the therapeutic potential of Eag1 in osteosarcoma remains elusive. In this study, we constructed an Ad5-Eag1-shRNA vector and evaluated its efficiency for Eag1 knockdown and its effects on osteosarcoma. Our results showed th...

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Bibliographic Details
Main Authors: Zhenqi Ding, Yong Zhou, Xinyu Wu, Daixing Zhong, Wenliang Zhai, Jin Wu
Format: Article
Language:English
Published: MDPI AG 2012-10-01
Series:International Journal of Molecular Sciences
Subjects:
Ether à go-go1 (Eag1)
vascular endothelial growth factor (VEGF)
proliferation
angiogenesis
short hairpin RNA(shRNA)
osteosarcoma
Online Access:http://www.mdpi.com/1422-0067/13/10/12573

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http://www.mdpi.com/1422-0067/13/10/12573

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