Evaluation of Neuropathological Features in the SOD1-G93A Low Copy Number Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Evaluation of Neuropathological Features in the SOD1-G93A Low Copy Number Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) still depicts an incurable and devastating disease. Drug development efforts are mostly based on superoxide dismutase 1 gene (SOD1)-G93A mice that present a very strong and early phenotype, allowing only a short time window for intervention. An alternative mouse m...

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Bibliographic Details
Main Authors: Agnes Molnar-Kasza, Barbara Hinteregger, Joerg Neddens, Roland Rabl, Stefanie Flunkert, Birgit Hutter-Paier
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neuroinflammation
muscle phenotype
spinal cord
survival rate
muscle strength
body weight
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.681868/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.681868/full

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