Synapse-to-Nucleus Communication through NFAT Is Mediated by L-type Ca2+ Channel Ca2+ Spike Propagation to the Soma

Synapse-to-Nucleus Communication through NFAT Is Mediated by L-type Ca2+ Channel Ca2+ Spike Propagation to the Soma

Summary: Long-term information storage in the brain requires continual modification of the neuronal transcriptome. Synaptic inputs located hundreds of micrometers from the nucleus can regulate gene transcription, requiring high-fidelity, long-range signaling from synapses in dendrites to the nucleus...

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Bibliographic Details
Main Authors: Angela R. Wild, Brooke L. Sinnen, Philip J. Dittmer, Matthew J. Kennedy, William A. Sather, Mark L. Dell’Acqua
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719303122

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http://www.sciencedirect.com/science/article/pii/S2211124719303122

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