Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy

Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy

Abstract Background The translocator protein (TSPO) has been identified as a positron emission tomography (PET)-visible biomarker of inflammation and promising immunotherapeutic target for the treatment of Alzheimer’s disease (AD). While TSPO ligands have been shown to reduce the accumulation of the...

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Bibliographic Details
Main Authors: Lauren H. Fairley, Naruhiko Sahara, Ichio Aoki, Bin Ji, Tetsuya Suhara, Makoto Higuchi, Anna M. Barron
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Complement
Microglia
Neuroinflammation
Peripheral benzodiazepine receptor
Tau
Online Access:https://doi.org/10.1186/s12974-021-02122-1

Internet

https://doi.org/10.1186/s12974-021-02122-1

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