Amyloid β Oligomers Increase ER-Mitochondria Ca2+ Cross Talk in Young Hippocampal Neurons and Exacerbate Aging-Induced Intracellular Ca2+ Remodeling

Amyloid β Oligomers Increase ER-Mitochondria Ca2+ Cross Talk in Young Hippocampal Neurons and Exacerbate Aging-Induced Intracellular Ca2+ Remodeling

Alzheimer’s disease (AD) is the most common neurodegenerative disorder and strongly associated to aging. AD has been related to excess of neurotoxic oligomers of amyloid β peptide (Aβo), loss of intracellular Ca2+ homeostasis and mitochondrial damage. However, the intimate mechanisms underlying the...

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Bibliographic Details
Main Authors: Maria Calvo-Rodriguez, Elena Hernando-Perez, Lucia Nuñez, Carlos Villalobos
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
calcium
Alzheimer’s disease
aging
endoplasmic reticulum
mitochondria
store-operated calcium entry
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00022/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00022/full

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