EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression

EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression

Abstract Background The EGFR-vIII mutation is the most common malignant event in GBM. Epigenetic reprogramming in EGFR-activated GBM has recently been suggested to downregulate the expression of tumour suppressor genes. Histone acetylation is important for chromatin structure and function. However,...

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Bibliographic Details
Main Authors: Hongyu Zhao, Yunfei Wang, Chao Yang, Junhu Zhou, Lin Wang, Kaikai Yi, Yansheng Li, Qixue wang, Jin Shi, Chunsheng Kang, Liang Zeng
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Clinical and Translational Medicine
Subjects:
EGFR-vIII
H2AZK4/7AC
Cell cycle
FK228
Glioblastoma
Online Access:http://link.springer.com/article/10.1186/s40169-020-0260-7

Internet

http://link.springer.com/article/10.1186/s40169-020-0260-7

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