Do chromatin changes around a nascent double strand DNA break spread spherically into linearly non-adjacent chromatin?

In the last decade, a lot has been done in elucidating the sequence of events that occur at the nascent double strand DNA break. Nevertheless, the overall structure formed by the DNA damage response factors around the break site, the repair focus, remains poorly understood. Although most of the data...

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Bibliographic Details
Main Author: Velibor eSavic
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Genetics
Subjects:
ATM
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00139/full