miR-204 silencing reduces mitochondrial autophagy and ROS production in a murine AD model via the TRPML1-activated STAT3 pathway

miR-204 silencing reduces mitochondrial autophagy and ROS production in a murine AD model via the TRPML1-activated STAT3 pathway

Mitochondrial dysfunction is an early feature of Alzheimer’s disease (AD), whereby accumulation of damaged mitochondria in conjunction with impaired mitophagy contributes to neurodegeneration. Various non-transcribed microRNAs (miRNAs) are involved in this process. In the present study, we aimed to...

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Bibliographic Details
Main Authors: Lu Zhang, Yu Fang, Xinyu Zhao, Yake Zheng, Yunqing Ma, Shuang Li, Zhi Huang, Lihao Li
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
Alzheimer’s disease
signal transducer and activator of transcription 3
microRNA-204
transient receptor potential mucolipin-1
mitochondrial autophagy
reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000457

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http://www.sciencedirect.com/science/article/pii/S2162253121000457

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