Differential Notch and TGFβ Signaling in Primary Colorectal Tumors and Their Corresponding Metastases

Background: Loss of epithelial morphology and the acquisition of mesenchymal characteristics may contribute to metastasis formation during colorectal tumorigenesis. The Wnt, Notch and TGFβ signaling pathways control tissue homeostasis and tumor development in the gut. The relationship between the ac...

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Main Authors:	Liesbeth M. Veenendaal, Onno Kranenburg, Niels Smakman, Annemarie Klomp, Inne H. M. Borel Rinkes, Paul J. van Diest
Format:	Article
Language:	English
Published:	Hindawi Limited 2008-01-01
Series:	Cellular Oncology
Online Access:	http://dx.doi.org/10.1155/2008/839076

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record_format	Article
spelling	doaj-6c9f4287e81c4dcd8a5cbc6f0b1fb4c82020-11-24T20:42:03ZengHindawi LimitedCellular Oncology1570-58701875-86062008-01-0130111110.1155/2008/839076Differential Notch and TGFβ Signaling in Primary Colorectal Tumors and Their Corresponding MetastasesLiesbeth M. Veenendaal0Onno Kranenburg1Niels Smakman2Annemarie Klomp3Inne H. M. Borel Rinkes4Paul J. van Diest5Department of Surgery, University Medical Center Utrecht, The NetherlandsDepartment of Surgery, University Medical Center Utrecht, The NetherlandsDepartment of Surgery, University Medical Center Utrecht, The NetherlandsDepartment of Surgery, University Medical Center Utrecht, The NetherlandsDepartment of Surgery, University Medical Center Utrecht, The NetherlandsDepartment of Pathology, University Medical Center Utrecht, The NetherlandsBackground: Loss of epithelial morphology and the acquisition of mesenchymal characteristics may contribute to metastasis formation during colorectal tumorigenesis. The Wnt, Notch and TGFβ signaling pathways control tissue homeostasis and tumor development in the gut. The relationship between the activity of these pathways and the expression of epithelial and mesenchymal markers was investigated in a series of primary colorectal tumors and their corresponding metastases.http://dx.doi.org/10.1155/2008/839076
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Liesbeth M. Veenendaal Onno Kranenburg Niels Smakman Annemarie Klomp Inne H. M. Borel Rinkes Paul J. van Diest
spellingShingle	Liesbeth M. Veenendaal Onno Kranenburg Niels Smakman Annemarie Klomp Inne H. M. Borel Rinkes Paul J. van Diest Differential Notch and TGFβ Signaling in Primary Colorectal Tumors and Their Corresponding Metastases Cellular Oncology
author_facet	Liesbeth M. Veenendaal Onno Kranenburg Niels Smakman Annemarie Klomp Inne H. M. Borel Rinkes Paul J. van Diest
author_sort	Liesbeth M. Veenendaal
title	Differential Notch and TGFβ Signaling in Primary Colorectal Tumors and Their Corresponding Metastases
title_short	Differential Notch and TGFβ Signaling in Primary Colorectal Tumors and Their Corresponding Metastases
title_full	Differential Notch and TGFβ Signaling in Primary Colorectal Tumors and Their Corresponding Metastases
title_fullStr	Differential Notch and TGFβ Signaling in Primary Colorectal Tumors and Their Corresponding Metastases
title_full_unstemmed	Differential Notch and TGFβ Signaling in Primary Colorectal Tumors and Their Corresponding Metastases
title_sort	differential notch and tgfβ signaling in primary colorectal tumors and their corresponding metastases
publisher	Hindawi Limited
series	Cellular Oncology
issn	1570-5870 1875-8606
publishDate	2008-01-01
description	Background: Loss of epithelial morphology and the acquisition of mesenchymal characteristics may contribute to metastasis formation during colorectal tumorigenesis. The Wnt, Notch and TGFβ signaling pathways control tissue homeostasis and tumor development in the gut. The relationship between the activity of these pathways and the expression of epithelial and mesenchymal markers was investigated in a series of primary colorectal tumors and their corresponding metastases.
url	http://dx.doi.org/10.1155/2008/839076
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Differential Notch and TGFβ Signaling in Primary Colorectal Tumors and Their Corresponding Metastases

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