Differential Notch and TGFβ Signaling in Primary Colorectal Tumors and Their Corresponding Metastases

Differential Notch and TGFβ Signaling in Primary Colorectal Tumors and Their Corresponding Metastases

Background: Loss of epithelial morphology and the acquisition of mesenchymal characteristics may contribute to metastasis formation during colorectal tumorigenesis. The Wnt, Notch and TGFβ signaling pathways control tissue homeostasis and tumor development in the gut. The relationship between the ac...

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Bibliographic Details
Main Authors: Liesbeth M. Veenendaal, Onno Kranenburg, Niels Smakman, Annemarie Klomp, Inne H. M. Borel Rinkes, Paul J. van Diest
Format: Article
Language:English
Published: Hindawi Limited 2008-01-01
Series:Cellular Oncology
Online Access:http://dx.doi.org/10.1155/2008/839076
Description
Summary:Background: Loss of epithelial morphology and the acquisition of mesenchymal characteristics may contribute to metastasis formation during colorectal tumorigenesis. The Wnt, Notch and TGFβ signaling pathways control tissue homeostasis and tumor development in the gut. The relationship between the activity of these pathways and the expression of epithelial and mesenchymal markers was investigated in a series of primary colorectal tumors and their corresponding metastases.
ISSN:1570-5870
1875-8606

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