A new synthetic class A amphipathic peptide analogue protects mice from diet-induced atherosclerosis

A new synthetic class A amphipathic peptide analogue protects mice from diet-induced atherosclerosis

Several synthetic class A peptide analogues have been shown to mimic many of the properties of human apo A-I in vitro. A new peptide [acetyl-(AspTrpLeuLysAlaPheTyrAspLysValPheGluLysPheLysGluPhePhe)-NH2; 5F], with increased amphipathicity, was administered by intraperitoneal injection, 20 μg/day for...

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Bibliographic Details
Main Authors: David W. Garber, Geeta Datta, Manjula Chaddha, M.N. Palgunachari, Susan Y. Hama, Mohamad Navab, Alan M. Fogelman, Jere P. Segrest, G.M. Anantharamaiah
Format: Article
Language:English
Published: Elsevier 2001-04-01
Series:Journal of Lipid Research
Subjects:
cholesterol
lipoproteins
metabolism
aorta
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520303734

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http://www.sciencedirect.com/science/article/pii/S0022227520303734

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