Strong purifying selection at synonymous sites in D. melanogaster.
Synonymous sites are generally assumed to be subject to weak selective constraint. For this reason, they are often neglected as a possible source of important functional variation. We use site frequency spectra from deep population sequencing data to show that, contrary to this expectation, 22% of f...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-05-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3667748?pdf=render |