Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function

Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function

Regulatory T cells (Treg cells) are essential for maintaining immune tolerance, and the dysfunction of Treg cells may cause autoimmune diseases and tumors. Forkhead box P3 (FOXP3) is the key transcription factor controlling Treg cell development and suppressive function. Mouse double minute 2 homolo...

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Bibliographic Details
Main Authors: Aiting Wang, Mengdi Yang, Rui Liang, Fangming Zhu, Fuxiang Zhu, Xinnan Liu, Yichao Han, Ruirong Lin, Xiaoxia Wang, Dan Li, Hecheng Li, Xiaojun Yuan, Hui Zhao, Bin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
E3 ubiquitin ligase
forkhead box P3 (FOXP3)
immunosuppression
mouse double minute 2 homolog (MDM2)
regulatory T cell (Treg cell)
ubiquitination
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01087/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01087/full

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