Capsaicin-Loaded Chitosan Nanocapsules for wtCFTR-mRNA Delivery to a Cystic Fibrosis Cell Line

Capsaicin-Loaded Chitosan Nanocapsules for wtCFTR-mRNA Delivery to a Cystic Fibrosis Cell Line

Cystic fibrosis (CF), a lethal hereditary disease caused by mutations in the <i>cystic fibrosis transmembrane conductance regulator</i> (CFTR) gene coding for an epithelial chloride channel, is characterized by an imbalanced homeostasis of ion and water transports in secretory epithelia....

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Bibliographic Details
Main Authors: A. Katharina Kolonko, Janes Efing, Yadira González-Espinosa, Nadine Bangel-Ruland, Willy van Driessche, Francisco M. Goycoolea, Wolf-Michael Weber
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Biomedicines
Subjects:
CFTR
ENaC
chitosan
mRNA therapy
nanocapsules
cystic fibrosis
Online Access:https://www.mdpi.com/2227-9059/8/9/364

Internet

https://www.mdpi.com/2227-9059/8/9/364

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