Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target

Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target

Inhibiting the interaction of menin with the histone methyltransferase MLL1 (KMT2A) has recently emerged as a novel therapeutic strategy. Beneficial therapeutic effects have been postulated in leukemia, prostate, breast, liver and in synovial sarcoma models. In those indications, MLL1 recruitment by...

Full description

Bibliographic Details
Main Authors: Krzysztof Brzezinka, Ekaterina Nevedomskaya, Ralf Lesche, Andrea Haegebarth, Antonius ter Laak, Amaury E. Fernández-Montalván, Uwe Eberspaecher, Nicolas D. Werbeck, Ursula Moenning, Stephan Siegel, Bernard Haendler, Ashley L. Eheim, Carlo Stresemann
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
chemical probe
menin-mll
target validation
cancer
solid tumor
Online Access:https://www.mdpi.com/2072-6694/12/1/201

Internet

https://www.mdpi.com/2072-6694/12/1/201

Similar Items