Phase separation of EML4–ALK in firing downstream signaling and promoting lung tumorigenesis

Phase separation of EML4–ALK in firing downstream signaling and promoting lung tumorigenesis

Abstract EML4–ALK fusion, observed in about 3%–7% of human lung adenocarcinoma, is one of the most important oncogenic drivers in initiating lung tumorigenesis. However, it still remains largely unknown about how EML4–ALK fusion exactly fires downstream signaling and drives lung cancer formation. We...

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Bibliographic Details
Main Authors: Zhen Qin, Honghua Sun, Meiting Yue, Xinwen Pan, Liang Chen, Xinhua Feng, Xiumin Yan, Xueliang Zhu, Hongbin Ji
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-021-00270-5

Internet

https://doi.org/10.1038/s41421-021-00270-5

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