A dimeric fluorescent protein yields a bright, red-shifted GEVI capable of population signals in brain slice

A dimeric fluorescent protein yields a bright, red-shifted GEVI capable of population signals in brain slice

Abstract A bright, red-shifted Genetically Encoded Voltage Indicator (GEVI) was developed using a modified version of the fluorescent protein, tdTomato. Dimerization of the fluorescent domain for ArcLight-type GEVIs has been shown to affect the signal size of the voltage-dependent optical signal. Fo...

Full description

Bibliographic Details
Main Authors: Bumjun Yi, Bok Eum Kang, Sungmoo Lee, Sophie Braubach, Bradley J. Baker
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Scientific Reports
Subjects:
Genetically Encoded Voltage Indicators (GEVI)
Voltage-sensing Domain (VSD)
tdTomato
Small Fractional Change
Acute Brain Slices
Online Access:https://doi.org/10.1038/s41598-018-33297-y

Internet

https://doi.org/10.1038/s41598-018-33297-y

Similar Items