Therapeutic vaccination with 4–1BB co-stimulation eradicates mouse acute myeloid leukemia

Therapeutic vaccination with 4–1BB co-stimulation eradicates mouse acute myeloid leukemia

Immunomodulatory therapies can effectively control haematological malignancies. Previously we reported the effectiveness of combination immunotherapies that centre on 4-1BB-targeted co-stimulation of CD8 + T cells, particularly when simultaneously harnessing the immune adjuvant properties of Natural...

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Bibliographic Details
Main Authors: Daniel Kerage, Megan S. F. Soon, Brianna L. Doff, Takumi Kobayashi, Michael D. Nissen, Pui Yeng Lam, Graham R. Leggatt, Stephen R. Mattarollo
Format: Article
Language:English
Published: Taylor & Francis Group 2018-10-01
Series:OncoImmunology
Subjects:
acute myeloid leukemia
mixed lineage leukemia
nkt cells
alpha-galactosylceramide
cancer vaccine
immunotherapy
monoclonal antibody
anti-pd-1
anti-4-1bb
cd8 t cells
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1486952

Internet

http://dx.doi.org/10.1080/2162402X.2018.1486952

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