An intrinsic lipid-binding interface controls sphingosine kinase 1 function[S]

An intrinsic lipid-binding interface controls sphingosine kinase 1 function[S]

Sphingosine kinase 1 (SK1) is required for production of sphingosine-1-phosphate (S1P) and thereby regulates many cellular processes, including cellular growth, immune cell trafficking, and inflammation. To produce S1P, SK1 must access sphingosine directly from membranes. However, the molecular mech...

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Bibliographic Details
Main Authors: Michael J. Pulkoski-Gross, Meredith L. Jenkins, Jean-Philip Truman, Mohamed F. Salama, Christopher J. Clarke, John E. Burke, Yusuf A. Hannun, Lina M. Obeid
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Journal of Lipid Research
Subjects:
sphingolipids
sphingosine-1-phosphate
hydrogen-deuterium exchange mass spectrometry
enzyme regulation
cell signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520331357

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http://www.sciencedirect.com/science/article/pii/S0022227520331357

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