Eukaryotic initiation factor 2α--a downstream effector of mammalian target of rapamycin--modulates DNA repair and cancer response to treatment.

Eukaryotic initiation factor 2α--a downstream effector of mammalian target of rapamycin--modulates DNA repair and cancer response to treatment.

In an effort to circumvent resistance to rapamycin--an mTOR inhibitor--we searched for novel rapamycin-downstream-targets that may be key players in the response of cancer cells to therapy. We found that rapamycin, at nM concentrations, increased phosphorylation of eukaryotic initiation factor (eIF)...

Full description

Bibliographic Details
Main Authors: Liron Tuval-Kochen, Shoshana Paglin, Gilmor Keshet, Yaniv Lerenthal, Charles Nakar, Tamar Golani, Amos Toren, Joachim Yahalom, Raphael Pfeffer, Yaacov Lawrence
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3808413?pdf=render

Internet

http://europepmc.org/articles/PMC3808413?pdf=render

Similar Items