Astrocytic GABA transporter activity modulates excitatory neurotransmission

Astrocytes monitor and regulate both excitatory and inhibitory synaptic activity. Here, the authors identify a novel form of neuronal-glia communication, by which astrocytes detect rises in GABA via the GABA transporter GAT-3; this results in adenosine release that acts presynaptically to inhibit ne...

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Bibliographic Details
Main Authors: Kim Boddum, Thomas P. Jensen, Vincent Magloire, Uffe Kristiansen, Dmitri A. Rusakov, Ivan Pavlov, Matthew C. Walker
Format: Article
Language:English
Published: Nature Publishing Group 2016-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13572