Ubiquitylation-independent activation of Notch signalling by Delta

Ubiquitylation-independent activation of Notch signalling by Delta

Ubiquitylation (ubi) by the E3-ligases Mindbomb1 (Mib1) and Neuralized (Neur) is required for activation of the DSL ligands Delta (Dl) and Serrate (Ser) to activate Notch signalling. These ligases transfer ubiquitin to lysines of the ligands' intracellular domains (ICDs), which sends them into...

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Bibliographic Details
Main Authors: Nicole Berndt, Ekaterina Seib, Soya Kim, Tobias Troost, Marvin Lyga, Jessica Langenbach, Sebastian Haensch, Konstantina Kalodimou, Christos Delidakis, Thomas Klein
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
Notch signalling
Mindbomb1
neuralized
cis-inhibition
E3-ligase
Delta
Online Access:https://elifesciences.org/articles/27346

Internet

https://elifesciences.org/articles/27346

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