Nuclear localization of Newcastle disease virus matrix protein promotes virus replication by affecting viral RNA synthesis and transcription and inhibiting host cell transcription

Abstract Nuclear localization of paramyxovirus proteins is crucial for virus life cycle, including the regulation of viral replication and the evasion of host immunity. We previously showed that a recombinant Newcastle disease virus (NDV) with nuclear localization signal mutation in the matrix (M) p...

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Bibliographic Details
Main Authors: Zhiqiang Duan, Shanshan Deng, Xinqin Ji, Jiafu Zhao, Chao Yuan, Hongbo Gao
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Veterinary Research
Online Access:http://link.springer.com/article/10.1186/s13567-019-0640-4