Extensive Basal Level Activation of Complement Mannose-Binding Lectin-Associated Serine Protease-3: Kinetic Modeling of Lectin Pathway Activation Provides Possible Mechanism

Extensive Basal Level Activation of Complement Mannose-Binding Lectin-Associated Serine Protease-3: Kinetic Modeling of Lectin Pathway Activation Provides Possible Mechanism

Serine proteases (SPs) are typically synthesized as precursors, termed proenzymes or zymogens, and the fully active form is produced via limited proteolysis by another protease or by autoactivation. The lectin pathway of the complement system is initiated by mannose-binding lectin (MBL)-associated S...

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Bibliographic Details
Main Authors: Gábor Oroszlán, Ráhel Dani, András Szilágyi, Péter Závodszky, Steffen Thiel, Péter Gál, József Dobó
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
innate immunity
complement
lectin pathway
serine protease
proenzyme
autoactivation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01821/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01821/full

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