miRNome profiling of LSC-enriched CD34+CD38−CD26+ fraction in Ph+ CML-CP samples from Argentinean patients: a potential new pharmacogenomic tool

miRNome profiling of LSC-enriched CD34+CD38−CD26+ fraction in Ph+ CML-CP samples from Argentinean patients: a potential new pharmacogenomic tool

Chronic myeloid leukemia (CML) is a myeloid stem cell neoplasm characterized by an expansion of myeloid progenitor cells and the presence of BCR-ABL1 oncoprotein. Since the introduction of specific BCR-ABL1 tyrosine kinase inhibitors (TKI), overall survival has improved significantly. However, under...

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Bibliographic Details
Main Authors: María Sol Ruiz, María Belén Sánchez, Simone Bonecker, Carolina Furtado, Daniel Koile, Patricio Yankilevich, Santiago Cranco, María del Rosario Custidiano, Josefina Freitas, Beatriz Moiraghi, Mariel Ana Pérez, Carolina Pavlovsky, Ana Inés Varela, Verónica Ventriglia, Julio César Sánchez Ávalos, Irene Larripa, Ilana Zalcberg, José Mordoh, Peter Valent, Michele Bianchini
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
microRNAs
metabolism
leukemic stem cell
leukemia
CD26
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.612573/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.612573/full

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