Chemoenzymatic Total Synthesis of (+)-10-Keto-Oxycodone from Phenethyl Acetate

Chemoenzymatic Total Synthesis of (+)-10-Keto-Oxycodone from Phenethyl Acetate

The total synthesis of (+)-10-keto-oxycodone was attained from phenethyl acetate in a stereoselective manner. Absolute stereochemistry was established via enzymatic dihydroxylation of phenethyl acetate with the recombinant strain JM109 (pDTG601A) that furnished the corresponding <i>cis</i&g...

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Bibliographic Details
Main Authors: Mary Ann Endoma-Arias, Helen Dela Paz, Tomas Hudlicky
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
enzymatic dihydroxylation
total synthesis
10-keto-oxycodone
can-mediated hydroxyazidation
aminohydroxylation
pinacol-type coupling
Online Access:https://www.mdpi.com/1420-3049/24/19/3477

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https://www.mdpi.com/1420-3049/24/19/3477

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