Mapping local structural perturbations in the native state of stefin B (cystatin B) under amyloid forming conditions

Mapping local structural perturbations in the native state of stefin B (cystatin B) under amyloid forming conditions

Unlike a number of amyloid-forming proteins, stefins, in particular stefin B (cystatin B) form amyloids under conditions where the native state predominates. In order to trigger oligomerization processes, the stability of the protein needs to be compromised, favoring structural re-arrangement howeve...

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Bibliographic Details
Main Authors: Robert eParamore, Gareth J Morgan, Peter J Davis, Carrie-anne eSharma, Andrea M Hounslow, Ajda eTaler-Vercic, Eva eZerovnik, Jonathan P Waltho, Matthew J Cliff, Rosemary Ann Staniforth
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Cystatin B
Cu (II) binding
precursors of amyloid
proline isomerization
stefin B
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00094/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00094/full

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