Motor, Visual and Emotional Deficits in Mice after Closed-Head Mild Traumatic Brain Injury Are Alleviated by the Novel CB2 Inverse Agonist SMM-189

Motor, Visual and Emotional Deficits in Mice after Closed-Head Mild Traumatic Brain Injury Are Alleviated by the Novel CB2 Inverse Agonist SMM-189

We have developed a focal blast model of closed-head mild traumatic brain injury (TBI) in mice. As true for individuals that have experienced mild TBI, mice subjected to 50–60 psi blast show motor, visual and emotional deficits, diffuse axonal injury and microglial activation, but no overt neuron lo...

Full description

Bibliographic Details
Main Authors: Anton Reiner, Scott A. Heldt, Chaela S. Presley, Natalie H. Guley, Andrea J. Elberger, Yunping Deng, Lauren D'Surney, Joshua T. Rogers, Jessica Ferrell, Wei Bu, Nobel Del Mar, Marcia G. Honig, Steven N. Gurley, Bob M. Moore II
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:International Journal of Molecular Sciences
Subjects:
TBI
deficits
microglia
CB2 receptors
therapy
Online Access:http://www.mdpi.com/1422-0067/16/1/758

Internet

http://www.mdpi.com/1422-0067/16/1/758

Similar Items