Reverse Remodeling in Human Heart Failure after Cardiac Resynchronization Therapy Is Associated With Reduced RHO-Kinase Activation

Reverse Remodeling in Human Heart Failure after Cardiac Resynchronization Therapy Is Associated With Reduced RHO-Kinase Activation

Background: Reverse remodeling is a clinically relevant endpoint in heart failure with reduced ejection fraction (HFrEF). Rho-kinase (ROCK) signaling cascade activation correlates with cardiac remodeling and left ventricular (LV) systolic dysfunction in HFrEF patients. Cardiac resynchronization ther...

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Bibliographic Details
Main Authors: Maria Paz Ocaranza, Jorge E. Jalil, Rodrigo Altamirano, Ana de León, Jackeline Moya, Alejandra Lonis, Luigi Gabrielli, Paul Mac Nab, Samuel Córdova, Alejandro Paredes, Ismael Vergara, Alex Bittner, Karime Sabat, Karla Pastorini
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
Rho kinase
heart failure
remodeling
reverse remodeling
resynchronization
Mypt, HFrEF
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.565724/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.565724/full

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