Bisavenathramide Analogues as Nrf2 Inductors and Neuroprotectors in In Vitro Models of Oxidative Stress and Hyperphosphorylation

Bisavenathramide Analogues as Nrf2 Inductors and Neuroprotectors in In Vitro Models of Oxidative Stress and Hyperphosphorylation

Oxidative stress is crucial to the outbreak and advancement of neurodegenerative diseases and is a common factor to many of them. We describe the synthesis of a library of derivatives of the 4-arylmethylen-2-pyrrolin-5-one framework by sequential application of a three-component reaction of primary...

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Bibliographic Details
Main Authors: Ángel Cores, Sheila Abril, Patrycja Michalska, Pablo Duarte, Ana I. Olives, M. Antonia Martín, Mercedes Villacampa, Rafael León, J. Carlos Menéndez
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Antioxidants
Subjects:
Nrf2–ARE pathway
neurodegenerative diseases
oxidative stress
Keap1
Nrf2 regulation
bisavenanthramides
Online Access:https://www.mdpi.com/2076-3921/10/6/941

Internet

https://www.mdpi.com/2076-3921/10/6/941

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