Molecular encapsulation of andrographolide in 2-hydroxypropyl-β-cyclodextrin cavity: synthesis, characterization, pharmacokinetic and in vitro antiviral activity analysis against SARS-CoV-2

Molecular encapsulation of andrographolide in 2-hydroxypropyl-β-cyclodextrin cavity: synthesis, characterization, pharmacokinetic and in vitro antiviral activity analysis against SARS-CoV-2

In present investigation, AND-2-HyP-β-CYD (Andrographolide-2-Hydroxypropyl-β-cyclodextrin) complex was synthesized and characterized for antiviral and pharmacokinetic profile. The linear host-guest relation suggested synthesis of a 1:1 complex of AND with 2-HyP-β-CYD by inclusion mode. The Kc, stabi...

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Bibliographic Details
Main Authors: Shashi Chandrama Singh, Dharmendra Kumar Khatri, Kulbhaskar Singh, Vinay Kumar Kanchupalli, Jitender Madan, Shashi Bala Singh, Harshpal Singh
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Heliyon
Subjects:
Andrographolide
Cyclodextrin
SARS-CoV-2
Pharmacokinetic
Bioavailability
Antiviral
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021018442

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http://www.sciencedirect.com/science/article/pii/S2405844021018442

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